sildenafil boosts effects of prazosin by pharmacodynamic synergism. Stay clear of or Use Alternate Drug. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr.
istradefylline will boost the degree or effect of sildenafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
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Monitor Intently (one)nebivolol boosts effects of sildenafil by additive vasodilation. Use Warning/Keep track of. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in people taking antihypertensive medications.
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Stay away from concomitant usage of tucatinib with CYP3A substrates, where nominal focus improvements could produce critical or life-threatening toxicities. If unavoidable, lower CYP3A substrate dose In accordance with solution labeling.
Keep track of Carefully (one)epoprostenol improves effects of sildenafil by additive vasodilation. Use Caution/Keep an eye on. Sildenafil has systemic vasodilatory properties and should further lower blood pressure in sufferers taking antihypertensive medications.
lorlatinib will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
rifabutin will decrease the extent or effect of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Powerful CYP3A4 inducers are envisioned to result in sizeable decreases in sildenafil plasma amounts
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Contraindicated (one)elvitegravir/cobicistat/emtricitabine/tenofovir DF raises levels of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Cobicistat is often a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are linked with critical and/or life-threatening activities; contraindication relates to chronic administration of sildenafil for PAH; for ED, not to exceed 25 mg in forty eight hr.
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